Product Name: Aminoglycoside Antibiotic Apramycin Sulfate Veterinary Medicine Storage Method: Light Proof Pharmacodynamic Influential Factors: Combined Medication Type: Veterinary Use Component: Chemical Synthetic Drugs Varieties: Infectious Disease Prevention Medicine  Main Ingredients: Apramycin Sulfate Character: Light Yellow to Brown Powder. Packing: 100g/Bag Transport Package: Carton Specification: 100g: 40g(40 million units) Origin: China Product Description English name:Apramycin Sulfate Soluble PowderMain ingredients:Apramycin SulfateCharacter:This product is light yellow to brown powder.Pharmacological action:Pharmacodynamics Apramycin is an aminoglycoside antibiotic,a variety of gram negative bacteria (such as Escherichia coli,Pseudomonas aeruginosa,Salmonella,Klebsiella,proteus,Pasteurella,hyodysenteriae,bronchitis from Bordetella) and Staphylococcus aureus and Mycoplasma have bactericidal activity.The chemical structure of Apramycin resistance by a variety of unique plasmid encoding enzyme inactivation,and gram negative bacteria to less resistant pathogenic Escherichia coli and Salmonella isolated from many animal is sensitive to it.Apramycin and other aminoglycosides has no cross resistance caused by chromosomal mutations.Pharmacokinetic study Oral administration can absorb part(especially the newborn),uptake of the same dose,and decreases with the age of animal growth.In the original form of drug excreted by the kidney.The calf has a half-life of 4.4 hours,sheep,rabbit,chicken has a half-life of 0.8 to 1.7 hours.Drug interactions:(1)have a synergistic effect in combination with penicillins or cephalosporins.(2)this product in alkaline environment enhanced antibacterial effect,and basic drugs(such as sodium bicarbonate,aminophylline and other combination) can enhance the antibacterial effect,but the toxicity increasing.When pH is more than 8.4,antibacterial effect was weakened.(3)with rust contact can make the drug inactivation.(4)with cephalosporins,dextran,potent diuretics(such as furosemide),erythromycin combination,can enhance the ototoxicity.(5)skeletal muscle relaxant (such as succinylcholine chloride etc.) or with the effect of the drug can enhance the neuromuscular blocking effect of this product.Indications:Mainly used in the treatment of gram negative bacterial infections of livestock and poultry,such as yellow scour of piglets,piglets with diarrhoea,colibacillosis,paratyphoid;colibacillosis and Pullorosis.Usage and dosage:Mixed drink:1L water,chicken 0.625~1.25g,for 5 days;every 1kg weight,pig 0.03125g,for 7 days.Adverse reaction:1.Apramycin sulfate most often caused by vestibular damage,the damage with the continuous administration of the drug accumulation and increased in a dose-dependent manner.2.excessive doses can lead to neuromuscular blocking effect.3.long term use can cause kidney damage.Note:1.the drug in case of rust prone to failure,mixed feeding machinery should pay attention to not rust,trace elements and the preparation of mixed use.2.the laying hens disabled.3.drinking water administration must be prepared that day.Withdrawal period:Pig 21,chicken for 7 days.Specificatioin:100g:40g(40 million units)Packing:100g*50bagStorage:Shading,sealed in a dry place.Product NameApramycin Sulfate Soluble PowderMain ingredientsApramycin SulfateCharacterlight yellow to brown powder.Usage and dosageMixed drink:1L water,chicken 0.625~1.25g,for 5 days;every 1kg weight,pig 0.03125g,for 7 days.Withdrawal periodPig 21,chicken for 7 days.Specificatioin100g:40g(40 million units)Packing100g*50bag