Product Name: Ciprofibrate /CAS: 52214-84-3 Model NO.: CAS: 52214-84-3 Product Description Ciprofibrate1. CAS No: 52214-84-32. MF: C13H14Cl2O33. Use: Hypercholesterolemia4. Appearance: White powder6. Introduction: N pharmacology, the fibrates are a class of amphipathic carboxylic acids. They are used for a range of metabolic disorders, mainly hypercholesterolemia(high cholesterol), and are therefore hypolipidemic agents. 7. Indications: Fibrates are used in accessory therapy in many forms of hypercholesterolemia, usually in combination with statins. [1] Clinical trials do support their use as monotherapy agents. Fibrates reduce the number of non-fatal heart attacks, but do not improve all-cause mortality and are therefore only indicated in those not tolerant to statins. [2][3]Although less effective in lowering LDL, fibrates improve HDL and triglyceride levels by increasing HDL levels and decreasing triglyceride levels, and seem to improve insulin resistance when the dyslipidemia is associated with other features of the metabolic syndrome (hypertension and diabetes mellitus type 2). They are therefore used in many hyperlipidemias. 8. Mechanism of action: Although used clinically since the 1930s, if not earlier, the mechanism of action of fibrates remained unelucidated until, in the 1990s, it was discovered that fibrates activate PPAR (peroxisome proliferator-activated receptors), especially PPARα . The PPARs are a class of intracellular receptors that modulatecarbohydrate and fat metabolism and adipose tissue differentiation. Activating PPARs induces the transcription of a number of genes that facilitate lipid metabolism. Fibrates are structurally and pharmacologically related to the thiazolidinediones, a novel class of anti-diabetic drugs that also act on PPARs (more specifically PPARγ )Fibrates are a substrate of (metabolized by) CYP3A4.